AKNA — AT-hook transcription factor
AKNA belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKNA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators BCR/AP1/NFKb pathway | ATF7IP, DNAJB14, FCHSD2, GOLGA4, IKZF3, INPP5D, MYCBP2, PDE7A +3 more | View in SCUBA |
| CD4⁺ T cells | TCR Activation Signaling TCR/AP1/NFKb pathway | ATP6V1A, BCL2L11, KIF20B, LAX1, NAA50, NEDD9, NPC1, PRKAR1A +6 more | View in SCUBA |
| Gamma-delta T cells | Transcription-RNA Coupling DNA/chromatin regulation | AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1, EDRF1 +26 more | |
| Hematopoietic progenitor cells | Lymphocyte Signaling Lymphcyte development | ADGRG5, AHR, CARD11, CORO1A, CYTH4, KIAA0930, LSP1, PAK1 +3 more | |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, ATM, ATP10D, BAZ2A, CHD9, CREBRF +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | STAT3 Cytokine Signaling Inflammation | AKAP13, AKIRIN2, ARGLU1, BDP1, GOLGB1, H1-2, LCP1, PPP4R3B +4 more | |
| Natural Killer cells | IFN-stimulated NK Inflammation | APOL6, ATM, CTSC, ITGAL, MBP, MXD1, PILRB, PTPRC +4 more | View in SCUBA |
About the gene
| Synonyms | KIAA1968 |
|---|---|
| Chromosome | 9: 114334156-114394405 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding |
| Biological process | Neurogenesis, Transcription, Transcription regulation |
Function
Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters. It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.