CCL14 — C-C motif chemokine ligand 14
CCL14 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1, LRRC1 +18 more | View in SCUBA |
About the gene
| Synonyms | CKb1, HCC-1, HCC-3, MCIF, NCC-2, SCYA14, SCYL2 |
|---|---|
| Chromosome | 17: 35983288-35987004 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
Function
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.