IL1R1 — Interleukin 1 receptor type 1

IL1R1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IL1R1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Regulatory T cell Immune regulation	ATP1B1, EBI3, FOXP3, GADD45A, GCNT1, GTF2H5, IL1R2, IPCEF1 +6 more	View in SCUBA
Endothelial	Venous EC Identity Endothelial cell development	ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, LRRC1 +18 more	View in SCUBA
Fibroblasts	IL-1 Receptor Signaling Inflammatory	CHIC2, GNAI1, MMD, PDLIM1, PRR16, SMIM3, ST3GAL1, TUSC3	View in SCUBA
Innate lymphoid cells	IFN-gamma Response Inflammation	APOL6, B3GALT5, DST, ELK3, GBP2, GBP4, GBP5, GOLGA8A +16 more	View in SCUBA
Macrophages	NRF2 Oxidative Stress Stress	ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more	View in SCUBA
Monocytes	TREM1 Inflammatory Signaling Innate immunity	AGO2, AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, ERRFI1 +6 more	View in SCUBA
Pericytes	Pericyte Identity Developmental	ADAMDEC1, EDIL3, EMID1, FOXF1, LRP1, LTBP4, MXRA5, NR2F1 +2 more	View in SCUBA
Smooth muscle cells	Hypoxia-NRF2 Activation Stress	LIMA1, MYADM, NFE2L2, REV3L, SERPINH1, UPF3A, VEGFA, ZEB2	View in SCUBA

About the gene

Synonyms	CD121A, D2S1473, IL1R, IL1RA
Chromosome	2: 102064544-102179874
Predicted location	Membrane, Secreted
Essential gene	No
Protein class	Cancer-related genes, CD markers, Enzymes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Predicted secreted proteins, Transporters
Molecular function	Hydrolase, Receptor
Biological process	Inflammatory response

Function

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa- B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.