Venous EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 27 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
NR2F2 (COUP-TFII) is the master transcription factor for venous EC identity. TGFBR3 and SMAD1 indicate active BMP/TGF-β signaling, which cooperates with NR2F2 in venous specification. IL1R1 adds inflammatory responsiveness. SEMA6A (semaphorin guidance), ZNF521, SSBP3, MAFB are TFs/co-regulators consistent with venous identity maintenance. DAPK1 and REV3L suggest stress/DNA damage responses. Upregulated in CD inflammation. As a neighbor to M41, both modules reflect venular EC programs, with M76 emphasizing identity/morphogen signaling and M41 emphasizing inflammatory surface molecules.
Genes
ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1, LRRC1, LRRC2, MAFB, MARVELD1, MBOAT2, MKNK2, NR2F2, PDIA5, REV3L, SAMD5, SEMA6A, SMAD1, SSBP3, ST6GAL1, TBC1D4, TGFBR3, TLL1, ZFP36L2, ZNF521
Most correlated modules
- Macrophage Contamination · correlation 0.92
- Venular Inflammatory Activation · correlation 0.89
- Quiescent EC Identity · correlation 0.86
- Arterial EC Identity · correlation 0.85
- Hypoxia Stress Response · correlation 0.81
- IL33 Alarmin Signaling · correlation 0.80
- Angiogenic Metabolic Adaptation · correlation 0.80
- Inflammatory Stress Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.