ACTN1 — Actinin alpha 1

ACTN1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ACTN1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Naive resting T cell T cell development	ADD3, ALKBH7, ANKRD55, ARMH1, CEP170, EDAR, GCNT4, HOOK2 +7 more	View in SCUBA
Endothelial	Venous EC Identity Endothelial cell development	AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1, LRRC1 +18 more	View in SCUBA
Fibroblasts	Focal Adhesion ECM Migration & adhesion	CLIC4, COL4A1, COL4A2, MPRIP, MRPL33, MYL6, NDUFA4, PARVA +6 more	View in SCUBA
Lymphatic endothelial	Actin Cytoskeletal Dynamics Cytoskeletal	BMAL2, NAV2, PFKP, PIK3C2B, PRRC2C, SLC39A14, SYNJ2	View in SCUBA
Macrophages	Inflammatory Monocyte Activation Inflammatory	ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9, DRAM1 +21 more	View in SCUBA
Monocytes	Inflammatory Metabolic Reprogramming Inflammatory	ADAM8, DGAT2, EAF1, GPAT3, MCTP2, PTPN7, SLC25A37, SLC2A3	View in SCUBA
Pericytes	Complement Regulatory Pericyte Inflammatory	CD63, CFH, IGFBP7, LGALS1, MGP, SELENOM, SERPING1	View in SCUBA
Smooth muscle cells	Contractile SMC phenotype Contractility	CNN1, DES, KCNMB1, LBR, MYLK, PDLIM7, SLMAP, SORBS1 +1 more	View in SCUBA

About the gene

Chromosome	14: 68874128-68979440
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Actin-binding

Function

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T- cell activation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.