EPB41L3 — Erythrocyte membrane protein band 4.1 like 3
EPB41L3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPB41L3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ACTN1, AK4, CCL14, CTTNBP2, DAPK1, FAM171A1, IL1R1, LRRC1 +18 more | View in SCUBA |
| Enterocytes | Mature colonocyte brush-border Epithelial development | AGMO, ATP8A1, CA3, CNKSR3, COBL, EMB, NGEF, PAG1 +2 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | CCSER2, CUX1, ECPAS, FUBP1, GATAD2A, GNA12, LRRFIP2, MED15 +10 more | View in SCUBA |
| Monocytes | G-protein Membrane Remodeling Migration & adhesion | ADA, ANKRD9, CXCL16, DNMBP, GFOD1, GNA12, GNA13, MRAS +7 more | View in SCUBA |
About the gene
| Synonyms | 4.1B, DAL1, KIAA0987 |
|---|---|
| Chromosome | 18: 5392381-5630700 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Actin-binding |
| Biological process | Apoptosis |
Function
Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.