CCR8 — C-C motif chemokine receptor 8
CCR8 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCR8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ACOT9, AHSP, AKIP1, BASP1, CASP1, CD177, CSF2RB, CTSZ +13 more | View in SCUBA |
About the gene
| Synonyms | CDw198, CKR-L1, CMKBR8, CMKBRL2, CY6, GPR-CY6, TER1 |
|---|---|
| Chromosome | 3: 39329709-39333680 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.