CTSZ — Cathepsin Z
CTSZ belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTSZ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lysosomal proteases Protein processing & ER | CD63, CD82, CNPY3, CTSA, CTSC, CTSD, FUT8, GALNT1 +2 more | View in SCUBA |
| CD4⁺ T cells | Activated Treg Immune regulation | ACOT9, AHSP, AKIP1, BASP1, CASP1, CCR8, CD177, CSF2RB +13 more | View in SCUBA |
| Enterocytes | Mature colonocyte absorptive Absorption | ADI1, BRI3, BTG1, CAMK2N1, FXYD3, GUCA2A, GUCA2B, HSD17B2 +9 more | View in SCUBA |
| Lymphatic endothelial | Caveolae Cytoskeletal Cytoskeletal | CALM1, CAVIN1, CRIP2, DYNLL1, EPHX1, GSTK1, HOXD8, HOXD9 +7 more | View in SCUBA |
| Macrophages | Lysosomal Hydrolase Program Lysosomal & pahgocytosis | AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more | View in SCUBA |
About the gene
| Synonyms | CTSX |
|---|---|
| Chromosome | 20: 58985686-59008238 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
Function
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.