CSF2RB — Colony stimulating factor 2 receptor subunit beta
CSF2RB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSF2RB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ACOT9, AHSP, AKIP1, BASP1, CASP1, CCR8, CD177, CTSZ +13 more | View in SCUBA |
| Endothelial | Leukocyte Recruitment Signaling Inflammation | BIRC3, CELSR1, HAPLN3, HSD3B7, IL34, IL7R, LTF, OLFM1 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | HPC Stemness Program Stemness | AMHR2, ARMC8, CASP3, CITED2, CNRIP1, DLC1, FBXO7, HBS1L +3 more | |
| Neutrophils | Bacterial Phagocytosis Program Phagocytosis | CASP4, CLEC7A, CSF3R, CYTH4, FCGR2A, LY96, SLC11A1, SLC25A37 +1 more | |
| Pericytes | UC Inflammatory Activation Inflammatory | BDKRB2, CD200, DUSP23, HLA-DQA1, MEOX1, NR5A2, PCDH17, RGCC +3 more | View in SCUBA |
About the gene
| Synonyms | betaGMR, CD131, IL3RB, IL5RB |
|---|---|
| Chromosome | 22: 36913628-36940439 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK- STAT pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.