ACOT9 — Acyl-CoA thioesterase 9
ACOT9 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACOT9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | AHSP, AKIP1, BASP1, CASP1, CCR8, CD177, CSF2RB, CTSZ +13 more | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1, CTNNBL1 +27 more | View in SCUBA |
About the gene
| Synonyms | ACATE2, CGI-16, MT-ACT48 |
|---|---|
| Chromosome | X: 23701055-23766475 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Serine esterase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Mitochondrial acyl-CoA thioesterase. Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoA), regulating their respective intracellular levels. Regulates both mitochondrial lipid and amino acid metabolism
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.