CISH — Cytokine inducible SH2 containing protein
CISH belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CISH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon response Anti-viral | ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, EIF2AK2, ERAP2, GBP1 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Survival Regulation Immune regulation | ACTR3, C11orf98, FARSA, GIMAP1, GIMAP4, GIMAP5, GIMAP7, MRPS18B +7 more |
About the gene
| Synonyms | CIS, CIS-1, G18, SOCS |
|---|---|
| Chromosome | 3: 50606489-50611774 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Signal transduction inhibitor |
| Biological process | Growth regulation, Ubl conjugation pathway |
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.