SCUBA

GIMAP4 — GTPase, IMAP family member 4

GIMAP4 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GIMAP4's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsGIMAP survival
Immune regulation
ABLIM1, AKT3, ANKRD13D, ARL4C, C16orf54, CA5B, COPA, CRBN +16 moreView in SCUBA
CD8⁺ T cellsEffector Memory CD8
T cell maturation
CLDND1, DENND2D, GIMAP1, GIMAP7, GPR183, GZMK, ITM2C, KLRG1 +3 moreView in SCUBA
EndothelialArterial EC Homeostasis
Endothelial cell development
APOL3, BMX, EXOC6, FAXDC2, FTH1, GABARAPL1, GAS6, GIMAP1 +10 moreView in SCUBA
Gamma-delta T cellsT Cell Survival
T cell maturation
CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP5, GIMAP7 +13 more
Lymphatic endothelialGIMAP mediated permeability
Mitochondrial & OxPhos
AGTRAP, CCNI, GIMAP1, GIMAP7, GPR146, HEBP1, LYL1, PSMB9 +2 moreView in SCUBA
MacrophagesInnate Antiviral Sensing
Innate immunity
ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 moreView in SCUBA
MonocytesGIMAP activation
Housekeeping
FGD2, GIMAP1, GIMAP6, GIMAP7, GIMAP8, IRF2, NAGK, P2RY13 +2 moreView in SCUBA
Mucosal-associated invariant T cellT cell Survival Regulation
Immune regulation
ACTR3, C11orf98, CISH, FARSA, GIMAP1, GIMAP5, GIMAP7, MRPS18B +7 more
Natural Killer cellsNK Lymphocyte Survival
Immune regulation
DENND2D, FGR, GIMAP1, GIMAP7, IL16, PTGDR, SLAMF6, TRAF3IP3View in SCUBA
NeutrophilsInnate DNA Sensing ISG
Antiviral
AIM2, IFI16, IRF2, RNF213, SHISA5, SP110, TMEM154, TNFSF10 +1 more
PericytesVascular Barrier Integrity
Migration & adhesion
C1orf115, FAM107A, GIMAP1, GIMAP7, ITGB4, JAM2, MYCT1, NRN1 +2 moreView in SCUBA

About the gene

SynonymsFLJ11110, HIMAP4, IAN1, IMAP4
Chromosome7: 150567369-150573953
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classPredicted intracellular proteins, Predicted membrane proteins

Function

During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.