T cell Survival Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
The GIMAP family (GIMAP1, GIMAP4, GIMAP5, GIMAP7) are GTPases essential for T and NK cell survival and homeostasis — their co-expression is a hallmark of mature lymphocyte identity. CISH is a cytokine-inducible negative regulator of TCR and IL-15 signaling, critical for MAIT cell regulation. PTPN6 (SHP-1) negatively regulates TCR and cytokine signaling. TRAF3IP3 links TRAF3 to T cell activation control. TNFAIP8L2 and TNFRSF1A add TNF-pathway immune regulation. SAMHD1 is an innate immune regulator. This module strongly represents T/MAIT cell survival and negative immune regulation.
Genes
ACTR3, C11orf98, CISH, FARSA, GIMAP1, GIMAP4, GIMAP5, GIMAP7, MRPS18B, PTPN6, SAMHD1, SH2D3C, TNFAIP8L2, TNFRSF1A, TRAF3IP3, TRIM27
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.87
- Actin Cytoskeletal Dynamics · correlation 0.82
- NF-κB Immune Survival · correlation 0.82
- mRNA Export & Processing · correlation 0.81
- MAIT Effector Maturation · correlation 0.81
- T cell Homeostasis · correlation 0.78
- Oxidative Stress Response · correlation 0.74
- ER & Mitochondrial Assembly · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.