GIMAP5 — GTPase, IMAP family member 5
GIMAP5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GIMAP5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | GIMAP survival Immune regulation | ABLIM1, AKT3, ANKRD13D, ARL4C, C16orf54, CA5B, COPA, CRBN +16 more | View in SCUBA |
| Gamma-delta T cells | T Cell Survival T cell maturation | CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP7 +13 more | |
| Macrophages | Resident Mac Niche Tissue homeostasis | AGGF1, ALDH1A1, ARL5A, CD163L1, CD209, CHN2, CLEC4F, CLIC2 +22 more | View in SCUBA |
| Monocytes | ER Stress Response Stress | CDKN1B, CFAP20, DDIT3, HSPA5, KLF2, KLF4, ODC1, RHOB +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Survival Regulation Immune regulation | ACTR3, C11orf98, CISH, FARSA, GIMAP1, GIMAP4, GIMAP7, MRPS18B +7 more | |
| Natural Killer cells | NK TGF-β Regulation Immune regulation | AOAH, CSK, NCR1, PPP1R18, PTPN6, PYCR2, SASH3, TGFBR2 +1 more | View in SCUBA |
About the gene
| Synonyms | HIMAP3, IAN4L1, IAN5 |
|---|---|
| Chromosome | 7: 150722253-150750033 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Predicted membrane proteins |
Function
Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.