SCUBA

GIMAP1 — GTPase, IMAP family member 1

GIMAP1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GIMAP1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsGIMAP survival
Immune regulation
ABLIM1, AKT3, ANKRD13D, ARL4C, C16orf54, CA5B, COPA, CRBN +16 moreView in SCUBA
CD8⁺ T cellsEffector Memory CD8
T cell maturation
CLDND1, DENND2D, GIMAP4, GIMAP7, GPR183, GZMK, ITM2C, KLRG1 +3 moreView in SCUBA
EndothelialArterial EC Homeostasis
Endothelial cell development
APOL3, BMX, EXOC6, FAXDC2, FTH1, GABARAPL1, GAS6, GIMAP4 +10 moreView in SCUBA
Gamma-delta T cellsT Cell Survival
T cell maturation
CASP1, CCDC107, CTU1, GEMIN7, GIMAP2, GIMAP4, GIMAP5, GIMAP7 +13 more
Lymphatic endothelialGIMAP mediated permeability
Mitochondrial & OxPhos
AGTRAP, CCNI, GIMAP4, GIMAP7, GPR146, HEBP1, LYL1, PSMB9 +2 moreView in SCUBA
MacrophagesInflammasome Oxidative Stress
Inflammatory
ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 moreView in SCUBA
MonocytesGIMAP activation
Housekeeping
FGD2, GIMAP4, GIMAP6, GIMAP7, GIMAP8, IRF2, NAGK, P2RY13 +2 moreView in SCUBA
Mucosal-associated invariant T cellT cell Survival Regulation
Immune regulation
ACTR3, C11orf98, CISH, FARSA, GIMAP4, GIMAP5, GIMAP7, MRPS18B +7 more
Natural Killer cellsNK Lymphocyte Survival
Immune regulation
DENND2D, FGR, GIMAP4, GIMAP7, IL16, PTGDR, SLAMF6, TRAF3IP3View in SCUBA
PericytesVascular Barrier Integrity
Migration & adhesion
C1orf115, FAM107A, GIMAP4, GIMAP7, ITGB4, JAM2, MYCT1, NRN1 +2 moreView in SCUBA

About the gene

SynonymsHIMAP1, IAN2, IMAP1, IMAP38
Chromosome7: 150716606-150724284
Predicted locationMembrane
Essential geneNo
Protein classPredicted membrane proteins

Function

May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.