CLPB — Caseinolytic mitochondrial matrix peptidase chaperone subunit B
CLPB belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLPB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Monocyte-Mac Iron Transport Iron metabolism | ARFIP1, BCL2L1, CDS2, EHD4, GNB4, HAVCR2, IVNS1ABP, MINDY2 +9 more | View in SCUBA |
About the gene
| Synonyms | ANKCLB, FLJ13152, HSP78, SKD3 |
|---|---|
| Chromosome | 11: 72285495-72434680 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I- mediated signal transduction and production of IFNB1 and pro- inflammatory cytokine IL6. Plays a role in granulocyte differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.