Monocyte-Mac Iron Transport
Gene co-expression module in Macrophages
| Category | Iron metabolism |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
Module is strongly enriched in mono_mac (monocyte-derived macrophages). Key hub genes: SLC11A2 (NRAMP2/DMT1, primary macrophage iron/divalent metal importer), HAVCR2 (TIM-3, canonical monocyte-derived macrophage marker), P2RX7 (purinergic receptor linked to inflammasome activation), SLC15A4 (endolysosomal peptide transporter supporting TLR7/9 signaling), BCL2L1 (survival), UGCG (glycosphingolipid synthesis), NRP2 (neuropilin-2, monocyte migration), TNS3 (adhesion/migration), EHD4 (endosomal recycling). SLC11A2 is a hallmark iron transporter in macrophages. The combination of iron transport, endolysosomal signaling, and monocyte identity markers defines this as a monocyte-derived macrophage iron/endolysosomal program.
Genes
ARFIP1, BCL2L1, CDS2, CLPB, EHD4, GNB4, HAVCR2, IVNS1ABP, MINDY2, NRP2, P2RX7, RBMS1, SLA, SLC11A2, SLC15A4, TMC6, TNS3, UGCG
Most correlated modules
- Hypoxia-driven Activation · correlation 0.94
- ER-Lysosome Trafficking · correlation 0.94
- Central Carbon Metabolism · correlation 0.94
- Myeloid Innate Signaling · correlation 0.92
- Myeloid Differentiation Identity · correlation 0.92
- Monocyte Phagocytic Identity · correlation 0.92
- Alternative Activation Lipid · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.