IVNS1ABP — Influenza virus NS1A binding protein

IVNS1ABP belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IVNS1ABP's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	BCR Signaling Regulation BCR/AP1/NFKb pathway	CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, MOB3A +5 more	View in SCUBA
CD4⁺ T cells	Transcriptional regulation DNA/chromatin regulation	CCNH, CWC25, DYNLL2, EIF2A, GOLGB1, JMJD1C, KRR1, LPIN2 +8 more	View in SCUBA
CD8⁺ T cells	TCR Proximal Signaling TCR Signaling	ACTN4, CD3G, CMIP, GALNT1, LCP2, MSN, PTPN22, PTPRA +3 more	View in SCUBA
Endothelial	VEGF Tip Cell Signaling Endothelial cell development	ADAMTS5, BDKRB2, CA2, CBLB, CCND1, DGKD, ESM1, GABRD +7 more	View in SCUBA
Innate lymphoid cells	ILC3 Transcriptional Identity Differentiation	ABHD5, AKT1S1, ARF4, ATP1A1, CKS2, EGR3, GADD45B, HES1 +12 more	View in SCUBA
Lymphatic endothelial	DNA Damage Apoptosis DNA/chromatin regulation	AZIN1, BAZ1A, HNRNPC, MAPK6, OTUD4, PHLDB2, SPEN, STX3 +4 more	View in SCUBA
Macrophages	Monocyte-Mac Iron Transport Iron metabolism	ARFIP1, BCL2L1, CDS2, CLPB, EHD4, GNB4, HAVCR2, MINDY2 +9 more	View in SCUBA
Monocytes	TNF-driven Activation Inflammatory	ATP13A3, CD44, DCUN1D3, DSE, GK, LAMB3, LITAF, POMP +3 more	View in SCUBA
Mucosal-associated invariant T cell	RNA Processing Stress RNA processing & translation	DDX3X, ETV3, HSPA5, KDM2A, NAF1, RALGAPA1, SFPQ, SLC2A3 +3 more
Neutrophils	Inflammasome IL-1 Response Cytokine & chemokine secretion	CSRNP1, EGR3, G0S2, IER3, IFRD1, IL1B, IL1RN, LPCAT1 +5 more
Pericytes	Cytoskeletal Remodeling Cytoskeletal	ARHGAP18, F2RL3, FSCN1, JUP, PASK, SEMA3F, TBCD, VWA1	View in SCUBA

About the gene

Synonyms	ARA3, HSPC068, KIAA0850, KLHL39, ND1, NS-1, NS1-BP
Chromosome	1: 185296388-185317273
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins
Biological process	Host-virus interaction, mRNA processing, mRNA splicing

Function

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro). May play a role in mRNA nuclear export. (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. The BTB and Kelch domains are required for splicing activity. Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.