ARFIP1 — ADP ribosylation factor interacting protein 1
ARFIP1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARFIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARRDC3, COG2, COQ7, DXO, EPM2AIP1, EPS8, HELQ, LETM2 +7 more | |
| Macrophages | Monocyte-Mac Iron Transport Iron metabolism | BCL2L1, CDS2, CLPB, EHD4, GNB4, HAVCR2, IVNS1ABP, MINDY2 +9 more | View in SCUBA |
About the gene
| Synonyms | HSU52521 |
|---|---|
| Chromosome | 4: 152779937-152918463 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.