GNB4 — G protein subunit beta 4
GNB4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNB4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Oxidative Stress Response Stress | AHR, CD151, CD59, CTTNBP2NL, DSTN, FLOT2, GNG5, HYAL2 +11 more | View in SCUBA |
| Macrophages | Monocyte-Mac Iron Transport Iron metabolism | ARFIP1, BCL2L1, CDS2, CLPB, EHD4, HAVCR2, IVNS1ABP, MINDY2 +9 more | View in SCUBA |
About the gene
| Chromosome | 3: 179396088-179451476 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Transducer |
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.