CNGA1 — Cyclic nucleotide gated channel subunit alpha 1
CNGA1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CNGA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene transcript bias Technical artifact | APC, CYP2C9, KLHL24, MAP3K2, PALS1, PLA2G4C, TRHDE | View in SCUBA |
| Smooth muscle cells | Capillary Pericyte Development | ADAP2, ADRA2A, ANKRD29, CCL8, ENPEP, EPHA2, EPS8L1, FAM162B +10 more | View in SCUBA |
About the gene
| Synonyms | CNCG, CNCG1, CNG1, RCNC1, RCNCa, RP49 |
|---|---|
| Chromosome | 4: 47935977-48016681 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Calcium channel, Ion channel, Ligand-gated ion channel, Sodium channel |
| Biological process | Calcium transport, Ion transport, Sensory transduction, Sodium transport, Transport, Vision |
Function
Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.