CCL8 — C-C motif chemokine ligand 8
CCL8 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Homeostatic Fibroblast State Housekeeping | ADAM28, APOE, CCL13, COLEC11, CRYBG3, ELANE, FABP4, FABP5 +5 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1, IFIT2 +13 more | View in SCUBA |
| Pericytes | NF-kB Chemokine Response Inflammatory | CCL2, CXCL1, CXCL2, NCOA7, PRDM1, SOD2, TNFAIP3 | View in SCUBA |
| Smooth muscle cells | Capillary Pericyte Development | ADAP2, ADRA2A, ANKRD29, CNGA1, ENPEP, EPHA2, EPS8L1, FAM162B +10 more | View in SCUBA |
About the gene
| Synonyms | HC14, MCP-2, SCYA8 |
|---|---|
| Chromosome | 17: 34319435-34321402 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted secreted proteins |
| Molecular function | Cytokine, Heparin-binding |
| Biological process | Chemotaxis, Inflammatory response |
Function
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.