ADRA2A — Adrenoceptor alpha 2A
ADRA2A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ADRA2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | FRC function Immune interaction | ANKRD29, CCL19, CCL21, CTSH, GP1BA, IL3RA, KCNK13, NPB +3 more | View in SCUBA |
| Hematopoietic progenitor cells | HSC Stemness Program Stemness | ALDH1A1, ATP6V0A2, CPPED1, DEPTOR, FCER1A, FREM1, PBX1, PGAP4 +4 more | |
| Smooth muscle cells | Capillary Pericyte Development | ADAP2, ANKRD29, CCL8, CNGA1, ENPEP, EPHA2, EPS8L1, FAM162B +10 more | View in SCUBA |
About the gene
| Synonyms | ADRA2, ADRA2R, ADRAR |
|---|---|
| Chromosome | 10: 111077029-111080907 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p- octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.