COMMD5 — COMM domain containing 5
COMMD5 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COMMD5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, CDC123, DNTTIP1, EIF3G, EIF4E2, FAM32A, ITGAE +8 more | View in SCUBA |
About the gene
| Synonyms | FLJ13008, HCaRG, HT002 |
|---|---|
| Chromosome | 8: 144841042-144853736 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin- RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation (By similarity). Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway (By similarity). Involved in kidney proximal tubule morphogenesis (By similarity). Down- regulates activation of NF-kappa-B.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.