Low-Coherence Mixed
Gene co-expression module in Macrophages
| Category | Technical artifact |
|---|---|
| Genes | 17 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 0 of 17 genes have a known function matching the annotation |
Why this annotation
All 17 genes show weak module membership, coherence is unknown, expression is uniform across subsets, and the gene list is functionally incoherent — spanning sialic acid biosynthesis (NANS), ubiquitin pathway (UBXN1), mitochondrial assembly (SDHAF2, ALKBH7), translation initiation (EIF4E2, EIF3G), cytoskeletal regulation (RFLNB, MARCKSL1), chromatin remodeling (SMARCB1), and epithelial markers (KRT10, ITGAE). No single biological program unifies these genes. This is a poorly defined catch-all module likely representing a technical artifact of co-expression network construction rather than a coherent biological program.
Genes
AAMP, ALKBH7, CDC123, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A, ITGAE, KRT10, MARCKSL1, NANS, RFLNB, RTF2, SDHAF2, SMARCB1, UBXN1
Most correlated modules
- ERAD Proteasome · correlation 0.97
- ER Protein Translocation · correlation 0.93
- Mixed Housekeeping · correlation 0.93
- Proteasome UPS · correlation 0.91
- Proteasome UPS · correlation 0.91
- Glycolytic Redox Metabolism · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.