ALKBH7 — AlkB homolog 7
ALKBH7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ALKBH7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive resting T cell T cell development | ACTN1, ADD3, ANKRD55, ARMH1, CEP170, EDAR, GCNT4, HOOK2 +7 more | View in SCUBA |
| Innate lymphoid cells | Mitochondrial Metabolic Housekeeping Mitochondrial & OxPhos | ATF6B, BCAS1, COQ8A, DDT, DNAJC4, DPM3, EIF3M, FDFT1 +16 more | View in SCUBA |
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, CDC123, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A, ITGAE +8 more | View in SCUBA |
About the gene
| Synonyms | MGC10974, SPATA11 |
|---|---|
| Chromosome | 19: 6372794-6375250 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Dioxygenase, Oxidoreductase |
| Biological process | Necrosis |
Function
May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.