CDC123 — Cell division cycle 123
CDC123 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC123's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteasome/translation Protein processing & ER | ANP32E, EIF4E, EIF5B, EMC8, MRPL20, NME7, PDXK, PKM +9 more | View in SCUBA |
| CD8⁺ T cells | Cellular Housekeeping Housekeeping | CHCHD2, COX5A, MRPL52, NUDT5, PDIA6, PSMB6, PSMC1, RBX1 +3 more | View in SCUBA |
| Endothelial | Inflammatory Kinase Signaling Inflammation | ANKRD28, CBL, CNN2, DGKH, EOGT, FADS3, FYN, MAP4K4 +7 more | View in SCUBA |
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A, ITGAE +8 more | View in SCUBA |
| Neutrophils | Immature Granulocyte Progenitor Developmental | ACSL4, AMPH, AVIL, ENSG00000282804, HAL, HRH2, MAOA, MPZL1 +3 more |
About the gene
| Synonyms | C10orf7, D123 |
|---|---|
| Chromosome | 10: 12195965-12250589 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
ATP-dependent protein-folding chaperone for the eIF2 complex. Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.