DNTTIP1 — Deoxynucleotidyltransferase terminal interacting protein 1
DNTTIP1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNTTIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, CDC123, COMMD5, EIF3G, EIF4E2, FAM32A, ITGAE +8 more | View in SCUBA |
About the gene
| Synonyms | C20orf167, dJ447F3.4, Tdif1 |
|---|---|
| Chromosome | 20: 45791954-45811427 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.