CRYZ — Crystallin zeta
CRYZ belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CRYZ's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | MAIT Effector Maturation T cell maturation | ASF1A, BET1, DAXX, ECI2, EOMES, FNTA, IRF3, LBH +10 more |
About the gene
| Chromosome | 1: 74705482-74733408 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase, RNA-binding |
Function
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.