EOMES — Eomesodermin

EOMES belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EOMES's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Effector-Memory CD8 T cell maturation	CD27, CD44, CMC1, CST7, CXCR3, DUSP2, F2R, HLA-E +8 more	View in SCUBA
Gamma-delta T cells	EOMES Effector Program T cell maturation	AGK, ANKZF1, ATG16L2, C6orf120, CARD8, CBX1, CDK5RAP3, CENPT +25 more
Mucosal-associated invariant T cell	MAIT Effector Maturation T cell maturation	ASF1A, BET1, CRYZ, DAXX, ECI2, FNTA, IRF3, LBH +10 more
Natural Killer cells	NK Maturation Program Differentiation	ARPC5L, BAALC, CDHR1, PDE7A, PDLIM1, S100PBP, SH2D1A, TESC +2 more	View in SCUBA

About the gene

Synonyms	TBR2
Chromosome	3: 27715949-27722711
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Adaptive immunity, Differentiation, Gastrulation, Immunity, Transcription, Transcription regulation

Function

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Required for differentiation and migration of unipolar dendritic brush cells. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.