MAIT Effector Maturation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
EOMES is the top-ranked functional immune gene — a master transcription factor for effector MAIT and NK cell programs. VSIR (VISTA) is an immune checkpoint receptor associated with exhaustion/regulation. ASF1A and DAXX are histone chaperones involved in chromatin remodeling during differentiation. IRF3 contributes to innate-like sensing. NPRL2 regulates mTORC1, relevant to effector differentiation. Together, EOMES + VSIR anchor this as an effector/maturation program with chromatin remodeling context, consistent with MAIT effector identity maintenance.
Genes
ASF1A, BET1, CRYZ, DAXX, ECI2, EOMES, FNTA, IRF3, LBH, MRPL34, NME6, NPRL2, PAGR1, PEF1, RIMOC1, SDAD1, SEPHS2, UBL4A, VSIR
Most correlated modules
- T cell Homeostasis · correlation 0.91
- Mitochondrial Biogenesis · correlation 0.90
- TCR Signaling Identity · correlation 0.87
- T cell Identity · correlation 0.83
- Chemokine Receptor Migration · correlation 0.82
- Chromatin Maintenance State · correlation 0.81
- T cell Survival Regulation · correlation 0.81
- Chromatin Complex Regulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.