ECI2 — Enoyl-CoA delta isomerase 2
ECI2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ECI2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more | |
| Mucosal-associated invariant T cell | MAIT Effector Maturation T cell maturation | ASF1A, BET1, CRYZ, DAXX, EOMES, FNTA, IRF3, LBH +10 more | |
| Natural Killer cells | NK Checkpoint Receptors Immune regulation | CD7, CD96, CRACR2B, DAPK2, ECH1, ISYNA1, KIR2DL4, MAP4 +5 more | View in SCUBA |
About the gene
| Synonyms | ACBD2, DRS1, HCA88, PECI |
|---|---|
| Chromosome | 6: 4115693-4135597 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Isomerase |
Function
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.