LBH — LBH regulator of WNT signaling pathway
LBH belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LBH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation signaling B cell maturation | ANKRD44, BLK, BTN3A2, EVI2B, GAPT, GPSM3, LTB, LY86 +9 more | View in SCUBA |
| CD4⁺ T cells | Ribosome biogenesis Housekeeping | APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LDHA, LSM5 +17 more | View in SCUBA |
| Endothelial | ECM Fibrotic Remodeling ECM remodeling | ADAMTS7, ANGPTL2, CD276, CETP, COL18A1, COLGALT1, DDI2, ERO1A +7 more | View in SCUBA |
| Gamma-delta T cells | Coinhibitory Checkpoint Exhaustion | BTN3A2, CDC25B, CDC42EP3, DDTL, FAM117A, FLOT2, GBP5, GGPS1 +12 more | |
| Mucosal-associated invariant T cell | MAIT Effector Maturation T cell maturation | ASF1A, BET1, CRYZ, DAXX, ECI2, EOMES, FNTA, IRF3 +10 more | |
| Pericytes | Myosin Phosphatase Regulation Cytoskeletal | CALM2, CRIP1, CRYAB, HCFC1R1, JAG1, MAP3K7CL, PHLDA2, PLAC9 +2 more | View in SCUBA |
| Smooth muscle cells | Wnt-Notch Modulation Development | CLMN, FRZB, HES4, MAP3K7CL, NET1, NRGN, NRIP2, PHLDA2 +1 more | View in SCUBA |
About the gene
| Chromosome | 2: 30231534-30323730 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.