CUEDC2 — CUE domain containing 2
CUEDC2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CUEDC2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CYC1, DCTN3, ERH +19 more |
About the gene
| Synonyms | C10orf66, MGC2491 |
|---|---|
| Chromosome | 10: 102423245-102432584 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Biological process | Ubl conjugation pathway |
Function
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.