DCTN3 — Dynactin subunit 3
DCTN3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DCTN3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon-stimulated genes Anti-viral | APOBEC3G, ARPC4, ARPC5L, BAK1, BST2, ECH1, ETFB, FAM104A +14 more | View in SCUBA |
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CUEDC2, CYC1, ERH +19 more | |
| Lymphatic endothelial | Mitochondrial OxPhos Complex Mitochondrial & OxPhos | ARL2, BLOC1S1, CHMP2A, CHURC1, COX5B, FIS1, MRPL43, NDUFA11 +5 more | View in SCUBA |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | ARF5, BUB3, CBX5, DUT, HMGN2, IDH2, KRTCAP2, MIF +7 more | View in SCUBA |
About the gene
| Synonyms | DCTN-22 |
|---|---|
| Chromosome | 9: 34613545-34620523 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.