ARF5 — ADP ribosylation factor 5
ARF5 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARF5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial Translation Mitochondrial & OxPhos | CBX6, CCDC124, CISD3, DCTN2, DDA1, EIF4E2, FKBP3, GID8 +17 more | View in SCUBA |
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, AURKAIP1, CCDC124, CUEDC2, CYC1, DCTN3, ERH +19 more | |
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | ADIPOR1, APH1A, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS, ERGIC3 +13 more | View in SCUBA |
| Natural Killer cells | Histone Variant Remodeling DNA regulation & transcription | C17orf49, DDOST, GNB2, H2AX, H2AZ1, H2AZ2, IFT25, MACROH2A1 +2 more | View in SCUBA |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2, MIF +7 more | View in SCUBA |
About the gene
| Chromosome | 7: 127588386-127591700 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | ER-Golgi transport, Protein transport, Transport |
Function
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.