CYC1 — Cytochrome c1
CYC1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | RNA Processing RNA processing | ANP32A, CCDC167, CDK4, CENPX, FDPS, GGCT, LSM3, LSM4 +14 more | View in SCUBA |
| CD4⁺ T cells | Respiratory chain assembly Mitochondrial & OxPhos | COA4, COA6, EBNA1BP2, ERCC1, POLR2E, PRELID3B, PSMD3, VMA21 | View in SCUBA |
| CD8⁺ T cells | Mitochondrial Metabolism Mitochondrial & OxPhos | ELAVL1, HINT2, PRDX3, RNPS1, SHMT2, SNRPA, TEX30, ZWILCH | View in SCUBA |
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CUEDC2, DCTN3, ERH +19 more | |
| Goblet cells | Mitochondrial OxPhos Mitochondrial & OxPhos | MAZ, NAA38, NDUFV1, PFKL, PPP1R1B, PXMP2, TECR | View in SCUBA |
| Innate lymphoid cells | Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos | AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, ERH, HSD17B10 +22 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
About the gene
| Synonyms | UQCR4 |
|---|---|
| Chromosome | 8: 144095039-144097525 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Translocase |
| Biological process | Electron transport, Respiratory chain, Transport |
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.