AURKAIP1 — Aurora kinase A interacting protein 1
AURKAIP1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AURKAIP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, BSG, CALM3, CLTB, CSNK2B, ERH +19 more | View in SCUBA |
| CD8⁺ T cells | Mitochondrial Housekeeping Housekeeping | CCDC167, ELOC, ITGB1BP1, MRPL57, NDUFB7, PDCD5, RBM17, SNRPA1 +2 more | View in SCUBA |
| Endothelial | Mitochondrial OxPhos Mitochondrial & OxPhos | ARPC1B, ATP5MF, NDUFB2, NDUFS6, PARVB, PFN1, POLR2E, SERF2 +3 more | View in SCUBA |
| Gamma-delta T cells | Transcriptional Elongation Control DNA/chromatin regulation | ANP32B, AP2M1, ARF5, CCDC124, CUEDC2, CYC1, DCTN3, ERH +19 more | |
| Goblet cells | Pyroptosis Stress Response Stress | ADAM15, CDC37, CENPX, COMTD1, DDX39A, EEF1D, GSDMD, INF2 +6 more | View in SCUBA |
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | ACADM, BUD23, CBX3, CMC2, COPB1, DNAJA2, DYNC1LI1, G3BP1 +19 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ACP1, ARPC5L, ATP6V1G1, C19orf53, CHMP2A, CIAO2B, CIB1, COPE +31 more | View in SCUBA |
About the gene
| Synonyms | AIP, AKIP, FLJ20608 |
|---|---|
| Chromosome | 1: 1373730-1375207 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Ribosomal proteins |
| Molecular function | Ribonucleoprotein, Ribosomal protein |
Function
May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.