Transcriptional Elongation Control
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 28 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes ERH, RALY, NELFB, and SUMO2 anchor this module in RNA processing and transcriptional elongation control. NELFB is a core subunit of the NELF (Negative Elongation Factor) complex that pauses RNA Pol II. SUMO2 drives SUMOylation of transcriptional regulators. SMARCE1 is a SWI/SNF chromatin remodeler. NUCKS1 is a chromatin-associated nuclear protein. PIN1 is a prolyl isomerase regulating transcription factor stability. ERH and RALY are RNA-binding proteins involved in splicing and mRNA stability. CYC1 and VDAC3 are peripheral mitochondrial members that may reflect co-regulation in active cells. The dominant program is transcriptional/chromatin regulation centered on RNA Pol II elongation control and post-translational modification of transcriptional machinery. Uniform expression supports a housekeeping identity.
Genes
ANP32B, AP2M1, ARF5, AURKAIP1, CCDC124, CUEDC2, CYC1, DCTN3, ERH, H3-3A, HPS1, KXD1, MRPL13, NDUFB11, NELFB, NUCKS1, PARK7, PIN1, RALY, RBBP7, SARNP, SMARCE1, SUMO2, TMEM160, TPRKB, TXN2, VDAC3, ZDHHC12
Most correlated modules
- Complex I Assembly · correlation 0.90
- Basal Cell Maintenance · correlation 0.89
- Endosomal Vesicle Trafficking · correlation 0.88
- Cellular Homeostasis · correlation 0.88
- Proteasome Complex · correlation 0.86
- General Housekeeping Mixed · correlation 0.85
- Oxidative Phosphorylation · correlation 0.85
- Glycolysis & Proteasome · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.