DAGLA — Diacylglycerol lipase alpha
DAGLA belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DAGLA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | DNA Damage Response Stress | ACSL4, AKNA, ALDH4A1, ATF7IP, ATM, BAIAP2, BCL11B, BCL9 +22 more | View in SCUBA |
About the gene
| Synonyms | C11orf11, DAGLALPHA, KIAA0659, NSDDR |
|---|---|
| Chromosome | 11: 61680391-61747001 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2- arachidonoylglycerol (2-AG). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG. Has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Also regulates neuroinflammatory responses in the brain, in particular, LPS- induced microglial activation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.