DCUN1D3 — Defective in cullin neddylation 1 domain containing 3
DCUN1D3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DCUN1D3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | JAK-STAT Cytokine Response Inflammatory | BCL2A1, CCRL2, CDC42EP2, IRF1, NFKBIE, PHLDA2, SNN, SOCS3 | View in SCUBA |
| Monocytes | TNF-driven Activation Inflammatory | ATP13A3, CD44, DSE, GK, IVNS1ABP, LAMB3, LITAF, POMP +3 more | View in SCUBA |
About the gene
| Synonyms | DKFZp686O0290, FLJ41725, MGC48972, SCCRO3 |
|---|---|
| Chromosome | 16: 20854925-20900358 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage. At the cell membrane, can promote and as well inhibit cullins neddylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.