BCL2A1 — BCL2 related protein A1

BCL2A1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

BCL2A1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NF-kB activation/survival BCR/AP1/NFKb pathway	ARL4C, CCR7, DDX21, GNG2, ICAM1, IRF2BPL, LMNA, NAMPT +9 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ABCF1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A, GNL3 +21 more	View in SCUBA
Gamma-delta T cells	XCL1/XCL2 Cytotoxic Activation cytotoxicity	CCL3L3, CCL4L2, FASLG, ICAM1, IRF8, PLEKHO2, RILPL2, SNX18 +6 more
Innate lymphoid cells	ILC Survival Residency Gut residency	ARID4B, BAZ1A, CD44, CSF2, CTSH, CXCL8, DUSP4, ENTPD1 +25 more	View in SCUBA
Macrophages	JAK-STAT Cytokine Response Inflammatory	CCRL2, CDC42EP2, DCUN1D3, IRF1, NFKBIE, PHLDA2, SNN, SOCS3	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Effector Activation Inflammation	ADGRE5, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10, EGR2 +10 more
Natural Killer cells	Autophagy-Inflammation Stress Stress	DDIT3, ICAM1, IFFO2, JMJD6, KLF10, MAP1LC3B, MKNK2, SIK3 +3 more	View in SCUBA
Neutrophils	Neutrophil Survival Program Inflammatory	B2M, CEBPB, EIF1, FTH1, FTL, H3-3A, H3-3B, PNRC1 +2 more

About the gene

Synonyms	ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1
Chromosome	15: 79960892-79971196
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Biological process	Apoptosis

Function

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.