NFKBIE — NFKB inhibitor epsilon
NFKBIE belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NFKBIE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | JAK-STAT Cytokine Response Inflammatory | BCL2A1, CCRL2, CDC42EP2, DCUN1D3, IRF1, PHLDA2, SNN, SOCS3 | View in SCUBA |
About the gene
| Synonyms | IKBE |
|---|---|
| Chromosome | 6: 44258166-44265788 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
Function
Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity. Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50- c-Rel) complexes. Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.