CCRL2 — C-C motif chemokine receptor like 2
CCRL2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCRL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Endothelial cell development | CDC42EP3, CGAS, CHSY1, CYTH1, HES5, HIPK3, ID1, ID3 +7 more | View in SCUBA |
| Gamma-delta T cells | Hypoxia Tissue Adaptation Tissue residence | ABCB1, ADAMTS17, ANKRD28, EPAS1, FAM3C, KLHL6, LDLRAD4, PHTF1 +10 more | |
| Macrophages | JAK-STAT Cytokine Response Inflammatory | BCL2A1, CDC42EP2, DCUN1D3, IRF1, NFKBIE, PHLDA2, SNN, SOCS3 | View in SCUBA |
| Monocytes | Inflammatory Stress Response Stress | ARL5B, ATF3, CD83, DUSP10, IL1B, NFE2L2, RASGEF1B, SGK1 +2 more | View in SCUBA |
| Neutrophils | CC Chemokine Secretion Cytokine & chemokine secretion | C15orf48, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, CD83, CDKN1A +4 more |
About the gene
| Synonyms | ACKR5, CKRX, CRAM-A, CRAM-B, HCR |
|---|---|
| Chromosome | 3: 46407166-46412997 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine- triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.