PHLDA2 — Pleckstrin homology like domain family A member 2
PHLDA2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHLDA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | NF-κB Stress Response Inflammatory | EGR3, NAMPT, NCOA7, NFIL3, PHLDA1, SAT1, SLC20A1, SOD2 +3 more | View in SCUBA |
| Lymphatic endothelial | DNA Damage Autophagy Stress | CKS2, COQ10B, GADD45A, HBP1, MAP1LC3B, MSX1, NR1D1, STX11 +2 more | View in SCUBA |
| Macrophages | JAK-STAT Cytokine Response Inflammatory | BCL2A1, CCRL2, CDC42EP2, DCUN1D3, IRF1, NFKBIE, SNN, SOCS3 | View in SCUBA |
| Pericytes | Myosin Phosphatase Regulation Cytoskeletal | CALM2, CRIP1, CRYAB, HCFC1R1, JAG1, LBH, MAP3K7CL, PLAC9 +2 more | View in SCUBA |
| Smooth muscle cells | Wnt-Notch Modulation Development | CLMN, FRZB, HES4, LBH, MAP3K7CL, NET1, NRGN, NRIP2 +1 more | View in SCUBA |
About the gene
| Synonyms | BWR1C, HLDA2, IPL, TSSC3 |
|---|---|
| Chromosome | 11: 2928273-2929420 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.