DEFA4 — Defensin alpha 4
DEFA4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEFA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Neutrophils | Primary Granule Antimicrobial Degranulation | CEACAM6, DEFA3, DUT, HNRNPAB, MS4A3, NUCB2, RNASE2, RNASE3 +1 more |
About the gene
| Synonyms | DEF4, HP-4 |
|---|---|
| Chromosome | 8: 6935820-6938306 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Defensin, Fungicide |
Function
Host-defense peptide that has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram- positive bacteria and fungi. Exhibits antimicrobial activity against Gram-negative E.coli and E.aerogenes and Gram-positive S.faecalis, S.aureus and B.cereus and the yeast C.albicans (in vitro). Interacts with pathogenic surface proteins and toxins, such as HIV-1 surface protein gp120 and B.anthracis anthrax lethal factor lef. Protects blood cells against infection with HIV-1 (in vitro). Inhibits enzymatic activity of B.anthracis lef/anthrax lethal factor (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production (in vitro).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.