MS4A3 — Membrane spanning 4-domains A3
MS4A3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MS4A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Eosinophil Differentiation Granulocyte development | CLC, DTWD2, EPX, ERN1, EXD3, IL5RA, PRG2 | |
| Monocytes | Multi-lineage Contamination Cell contamination | AZU1, CLU, CYP19A1, E2F2, ELANE, GM2A, GYPC, ITGB7 +4 more | View in SCUBA |
| Neutrophils | Primary Granule Antimicrobial Degranulation | CEACAM6, DEFA3, DEFA4, DUT, HNRNPAB, NUCB2, RNASE2, RNASE3 +1 more |
About the gene
| Synonyms | CD20L, HTM4 |
|---|---|
| Chromosome | 11: 60056587-60071115 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.