Primary Granule Antimicrobial
Gene co-expression module in Neutrophils
| Category | Degranulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are strongly enriched for neutrophil primary/azurophil granule components: DEFA3 and DEFA4 (alpha-defensins, hallmark azurophil granule antimicrobial peptides), RNASE3 and RNASE2 (granule-associated ribonucleases with antimicrobial activity), CEACAM6 (neutrophil surface adhesion molecule), MS4A3 (granulocyte progenitor/promyelocyte marker), SPN/CD43 (leukocyte sialophorin), NUCB2 (calcium-binding granule protein), DUT (dUTPase, housekeeping but expressed in proliferating precursors), HNRNPAB. The co-expression of defensins with MS4A3 places this module in immature/band neutrophils or promyelocytes expressing primary granule contents. Compared to M60 (secondary/tertiary granule neighbor), this module represents earlier-stage granule biogenesis.
Genes
CEACAM6, DEFA3, DEFA4, DUT, HNRNPAB, MS4A3, NUCB2, RNASE2, RNASE3, SPN
Most correlated modules
- Mitotic Spindle · correlation 0.91
- Translation Initiation · correlation 0.87
- Proteostasis RNA Metabolism · correlation 0.79
- S-G2-M Cell Cycle · correlation 0.75
- mRNA Splicing Processing · correlation 0.72
- Translational Housekeeping · correlation 0.71
- RNA Splicing · correlation 0.71
- Immature Neutrophil Granule · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.