SCUBA

HNRNPAB — Heterogeneous nuclear ribonucleoprotein A/B

HNRNPAB belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HNRNPAB's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsmRNA splicing factors
RNA processing
CALM1, CALM2, CKS2, CYCS, EIF4A3, HNRNPA0, HNRNPA2B1, MRPS6 +12 moreView in SCUBA
CD4⁺ T cellsRNA processing
RNA processing
AARSD1, ABHD14A, AMD1, CALM2, CDKN2AIP, CHMP1B, FRAT1, HNRNPDL +7 moreView in SCUBA
CD8⁺ T cellsEpigenetic Chromatin Maintenance
DNA/chromatin regulation
BAZ1B, DDX46, DNMT1, NASP, NOP56, SET, SMC1A, SMC3 +2 moreView in SCUBA
EndothelialSpliceosome snRNP Assembly
RNA processing & translation
BAX, CBX3, CCT2, CCT4, EIF3I, FGFR1, HNRNPC, NAP1L1 +6 moreView in SCUBA
Gamma-delta T cellsIRF4 T-cell Activation
T cell maturation
APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B +14 more
Glial cellsRNA Splicing Processing
RNA processing & translation
DDX3X, DDX5, HNRNPA2B1, HNRNPDL, HNRNPH1, MAFB, NES, RND3 +2 moreView in SCUBA
Goblet cellshnRNP RNA Processing
RNA processing & translation
CCT2, HNRNPD, HNRNPR, ILF3, IMPA2, SERBP1, SET, TAF15View in SCUBA
Hematopoietic progenitor cellsRibosome Biogenesis
Housekeeping
DDX21, DKC1, GNL3, LRPPRC, NOLC1, NOP56, NOP58, PA2G4 +2 more
Innate lymphoid cellsRNA-binding & Splicing
RNA processing & translation
CALM1, DYNLL1, FUS, HNRNPA2B1, NCL, NUDC, PPIG, SAP18 +4 moreView in SCUBA
MacrophagesReplication Chromatin Assembly
Cell cycle
ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 moreView in SCUBA
Natural Killer cellshnRNP RNA Processing
RNA processing & translation
CBX3, GNG5, HNRNPA2B1, HNRNPA3, RAN, SLC25A5, YWHAEView in SCUBA
NeutrophilsPrimary Granule Antimicrobial
Degranulation
CEACAM6, DEFA3, DEFA4, DUT, MS4A3, NUCB2, RNASE2, RNASE3 +1 more

About the gene

SynonymsABBP1, FLJ40338, HNRPAB
Chromosome5: 178204533-178211163
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Molecular functionRNA-binding

Function

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.