DENND2A — DENN domain containing 2A
DENND2A belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DENND2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Colonocyte Senescence Senescence & shedding | ACADM, CDIPT, EAPP, ENDOD1, FCGRT, FOXN3, FTH1, GPX4 +11 more | View in SCUBA |
About the gene
| Synonyms | FAM31D, KIAA1277 |
|---|---|
| Chromosome | 7: 140518420-140673993 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
| Biological process | Protein transport, Transport |
Function
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.